We definitely recommend running in your amplifier to ensure you are achieving the best possible performance.
The running in process ensures certain components (such as capacitors) settle and perform at a constant. The amplifier will sound excellent out of the box, and will only improve as it is run in. This running in time can vary, but we generally quote about 36 hours.
You can do this all at once if you need your amplifier to be at optimum performance quickly, or you can use your amplifier as you normally would and over time the sound will gradually improve.
Regardless of the option you choose, the overall result will be the same.